Weichang Chen Selected Research

Therapeutics

1/2023	Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer.
1/2023	MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey.
2/2021	B7-H3 is spliced by SRSF3 in colorectal cancer.
1/2021	B7-H3 suppresses doxorubicin-induced senescence-like growth arrest in colorectal cancer through the AKT/TM4SF1/SIRT1 pathway.
12/2017	Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells.
10/2017	Prediction of radiosensitive patients with gastric cancer by developing gene signature.
1/2016	Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer.

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Weichang Chen Research Topics

Disease

47	Neoplasms (Cancer) 01/2024 - 10/2003
25	Stomach Neoplasms (Stomach Cancer) 12/2023 - 01/2010
16	Colorectal Neoplasms (Colorectal Cancer) 11/2023 - 03/2011
14	Carcinogenesis 01/2023 - 03/2011
12	Neoplasm Metastasis (Metastasis) 12/2023 - 03/2011
10	Colonic Neoplasms (Colon Cancer) 09/2021 - 10/2003
5	Colitis 01/2023 - 01/2016
5	Inflammation (Inflammations) 01/2023 - 01/2016
4	Adenocarcinoma 01/2022 - 12/2016
4	Carcinoma (Carcinomatosis) 03/2018 - 01/2010
3	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 06/2024 - 01/2019
3	Crohn Disease (Crohn's Disease) 01/2023 - 06/2012
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/2022 - 05/2019
3	Disease Progression 10/2017 - 06/2013
2	Colitis-Associated Neoplasms 01/2023 - 01/2016
2	Pancreatitis 10/2018 - 04/2012
2	Fibrosis (Cirrhosis) 05/2018 - 01/2015
2	Body Weight (Weight, Body) 05/2018 - 01/2015
2	Hepatocellular Carcinoma (Hepatoma) 05/2018 - 05/2014
2	Ulcerative Colitis 09/2017 - 01/2016
2	Melanoma (Melanoma, Malignant) 01/2011 - 01/2010
1	Wounds and Injuries (Trauma) 11/2023
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/2023
1	Dysbiosis 01/2023
1	Infections 06/2022
1	Dry Eye Syndromes (Dry Eye Syndrome) 03/2022
1	Thrombocytopenia (Thrombopenia) 03/2022
1	Weight Loss (Weight Reduction) 11/2021

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2010
10	MicroRNAs (MicroRNA)IBA 06/2021 - 03/2011
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2014
6	CytokinesIBA 06/2022 - 01/2010
6	Therapeutic UsesIBA 08/2017 - 10/2003
4	Messenger RNA (mRNA)IBA 04/2022 - 04/2010
4	Polysaccharides (Glycans)IBA 11/2021 - 01/2016
4	MucinsIBA 01/2020 - 01/2015
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2016 - 09/2009
3	AntibodiesIBA 06/2024 - 01/2019
3	AutoantibodiesIBA 06/2024 - 01/2019
3	Sirtuin 1IBA 01/2023 - 01/2021
3	CateninsIBA 01/2023 - 12/2017
3	CaspasesIBA 10/2020 - 01/2016
3	Interleukin-6 (Interleukin 6)IBA 09/2020 - 01/2010
3	DNA (Deoxyribonucleic Acid)IBA 09/2020 - 04/2010
3	Small Interfering RNA (siRNA)IBA 03/2018 - 08/2017
3	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 01/2015
2	CholesterolIBA 01/2023 - 07/2022
2	Caspase 1 (ICE Protease)IBA 01/2023 - 01/2016
2	Circular RNAIBA 07/2022 - 12/2021
2	Dextran SulfateIBA 11/2021 - 09/2017
2	Granzymes (Granzyme)IBA 09/2021 - 01/2020
2	Cadherins (E-Cadherin)IBA 04/2021 - 05/2016
2	ElementsIBA 09/2020 - 08/2015
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2020 - 01/2011
2	Tn antigenIBA 01/2020 - 01/2016
2	Glycoproteins (Glycoprotein)IBA 01/2020 - 01/2019
2	Transcription Factors (Transcription Factor)IBA 10/2018 - 05/2016
2	Indicators and Reagents (Reagents)IBA 01/2018 - 05/2015
2	LuciferasesIBA 01/2018 - 06/2013
2	Cisplatin (Platino)FDA LinkGeneric 08/2017 - 01/2016
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2016 - 01/2016
2	4-1BB Ligand (4 1BB Ligand)IBA 06/2015 - 02/2013
2	VaccinesIBA 06/2015 - 02/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2012 - 01/2010
1	CCR6 ReceptorsIBA 06/2024
1	LigandsIBA 06/2024
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2023
1	Tripartite Motif ProteinsIBA 12/2023
1	6-methyladenineIBA 11/2023
1	AldehydesIBA 11/2023
1	PowdersIBA 11/2023
1	Dextrans (Dextran)FDA Link 11/2023
1	Schiff Bases (Schiff Base)IBA 11/2023
1	HydrogelsIBA 11/2023
1	AmidesIBA 11/2023
1	N-methyladenosineIBA 11/2023
1	pseudouridine synthasesIBA 01/2023
1	Infliximab (Remicade)FDA Link 01/2023
1	Dietary Fats (Dietary Fat)IBA 01/2023
1	Butyrates (Butyrate)IBA 01/2023
1	Tumor Biomarkers (Tumor Markers)IBA 07/2022
1	dioscinIBA 06/2022
1	rottlerinIBA 04/2022
1	Insulin-Like PeptidesIBA 04/2022
1	Carrier Proteins (Binding Protein)IBA 04/2022
1	Complement C4 (Complement Component 4)IBA 03/2022
1	Monoclonal AntibodiesIBA 09/2021
1	Immune Checkpoint InhibitorsIBA 09/2021
1	Lactate Dehydrogenase 5IBA 06/2021
1	RNA Splicing FactorsIBA 02/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021
1	Death Domain ReceptorsIBA 10/2020
1	Caspase 8 (Caspase-8)IBA 10/2020
1	SurvivinIBA 10/2020

Therapy/Procedure

7	Therapeutics 01/2023 - 01/2016
5	Immunotherapy 11/2023 - 02/2013
2	Neoadjuvant Therapy 01/2022 - 10/2020
2	Radiotherapy 10/2020 - 10/2017
1	Endoscopes 06/2023
1	Drug Therapy (Chemotherapy) 01/2021